A Multifunctional Magnetic Composite Material as a Drug Delivery System and a Magnetic Resonance Contrast Agent. (1st April 2014)

• Record Type: Journal Article
• Authors: Zhang, Guilong; Gao, Junlan; Qian, Junchao; Cai, Dongqing; Zheng, Kang; Yu, Zhiwu; Wang, Junfeng; Zhong, Kai; Zhang, Xin; Wu, Zhengyan
• Is Part Of: Particle and particle systems characterization. Volume 31:Number 9(2014:Sep.)
• Page Start: 976
• Page End: 984
• Publication Date: 2014-04-01
• Subjects: Particles -- Periodicals; 620.43
• DOI: 10.1002/ppsc.201300366
• Languages: English
• ISSNs: 0934-0866

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Magnetic iron oxide coated in hydrogenation silica (Fe<sub>3</sub>O<sub>4</sub>@HSiO<sub>2</sub>) is constructed as both a tumor drug carrier and a magnetic resonance (MR) contrast agent. Colchicine (COLC) is loaded in Fe<sub>3</sub>O<sub>4</sub>@HSiO<sub>2</sub> with the highest amount of 28.3 wt% at pH 9. The release performance of COLC can be controlled by pH, as the porous HSiO<sub>2</sub> shell can partially shed at pH below 3.0 to facilitate the release of COLC. MR imaging (MRI) tests prove that Fe<sub>3</sub>O<sub>4</sub>@HSiO<sub>2</sub> at pH 3.0 (H<sup>+</sup>‐Fe<sub>3</sub>O<sub>4</sub>@HSiO<sub>2</sub>) shows a stronger MR contrast enhancement than Fe<sub>3</sub>O<sub>4</sub>. Cytotoxicity experiment indicates that Fe<sub>3</sub>O<sub>4</sub>@HSiO<sub>2</sub> has excellent biocompatibility and magnetic targeting performance. Additionally, COLC‐loaded Fe<sub>3</sub>O<sub>4</sub>@HSiO<sub>2</sub> (Fe<sub>3</sub>O<sub>4</sub>@HSiO<sub>2</sub>–COLC) displays a higher inhibition effect on tumor cells under a magnetic field than free COLC. The visibility upon MRI, high targeting, and pH‐controlled release characteristics of Fe<sub>3</sub>O<sub>4</sub>@HSiO<sub>2</sub>–COLC are favorable to achieve the aim of reducing side effects to normal tissues, making Fe<sub>3</sub>O<sub>4</sub>@HSiO<sub>2</sub>–COLC an attractive drug delivery system for nanomedicine.</p> </abstract>