Fabrication of a heparin–PVA complex hydrogel for application as a vascular access. Issue 7 (27th February 2014)

• Record Type: Journal Article
• Authors: Negishi, Jun; Nam, Kwangwoo; Kimura, Tsuyoshi; Hashimoto, Yoshihide; Funamoto, Seiichi; Higami, Tetsuya; Fujisato, Toshiya; Kishida, Akio
• Is Part Of: Journal of biomedical materials research. Volume 102:Issue 7(2014:Oct.)
• Page Start: 1426
• Page End: 1433
• Publication Date: 2014-02-27
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.b.33121
• Languages: English
• ISSNs: 1552-4973

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>A high hydrostatic pressure method, which can apply over 600 MPa pressure was employed for preparing a hydrogel of poly(vinyl alcohol) (PVA) loaded with heparin. The aim of this study was to fabricate a heparin–PVA hydrogel conduit and evaluate its potential for vascular access. Heparin–PVA complex hydrogel showed suppressed heparin release and prevented clot formation, depending on the molecular weight of the PVA. Strength of the hydrogel conduit was increased by embedding a Dacron^® mesh between two PVA layers. The tubular heparin–PVA complex hydrogel displayed a burst pressure of 750 mmHg. The tubular heparin–PVA complex hydrogel did not show any occlusion or burst for 2 weeks after implantation, implying that this heparin–PVA complex hydrogel shows high potential for use as a vascular access. This is the first report on the preparation of a multilayered PVA hydrogel with heparin embedded on one side only. The proposed approach could be expanded to the fabrication of various biomaterials for specific purposes. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1426–1433, 2014.</p> </abstract>