Macromolecular Prodrugs of Ribavirin: Concerted Efforts of the Carrier and the Drug. Issue 9 (10th January 2014)

• Record Type: Journal Article
• Authors: Smith, Anton A. A.; Wohl, Benjamin M.; Kryger, Mille B. L.; Hedemann, Natasha; Guerrero‐Sanchez, Carlos; Postma, Almar; Zelikin, Alexander N.
• Is Part Of: Advanced healthcare materials. Volume 3:Issue 9(2014:Sep.)
• Page Start: 1404
• Page End: 1407
• Publication Date: 2014-01-10
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201300637
• Languages: English
• ISSNs: 2192-2640

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adhm201300637-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Polymers in tune</bold>. Automated parallel polymer synthesis is developed to obtain libraries of macromolecular prodrugs of ribavirin, a broad‐spectrum antiviral agent. As many as 10 identified lead polymer conjugates exhibit therapeutic efficacy matching that of the pristine drug and at the same time suppressed the origin of the main side effect of ribavirin. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh18r68k3s" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>