Drug Delivery: Macromolecular Prodrugs of Ribavirin: Concerted Efforts of the Carrier and the Drug (Adv. Healthcare Mater. 9/2014). Issue 9 (8th September 2014)

• Record Type: Journal Article
• Authors: Smith, Anton A. A.; Wohl, Benjamin M.; Kryger, Mille B. L.; Hedemann, Natasha; Guerrero‐Sanchez, Carlos; Postma, Almar; Zelikin, Alexander N.
• Is Part Of: Advanced healthcare materials. Volume 3:Issue 9(2014:Sep.)
• Page Start: 1520
• Page End: 1520
• Publication Date: 2014-09-08
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201470047
• Languages: English
• ISSNs: 2192-2640

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adhm201470047-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Automated parallel synthesis is applied by A. Postma, A. Zelikin, and team on page 1404 to obtain libraries of macromolecular prodrugs of ribavirin. Polymers differ in their average molar mass and drug content, the two parameters independently vary in broad respective ranges. Screening the libraries for intracellular activity identifies at least 10 formulations with efficacy matching that of the drug and at the same time significantly reducing toxicity. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh18r68m0n" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>