Assessing Cellular Response to Functionalized α‐Helical Peptide Hydrogels. Issue 9 (24th March 2014)

• Record Type: Journal Article
• Authors: Mehrban, Nazia; Abelardo, Edgardo; Wasmuth, Alexandra; Hudson, Kieran L.; Mullen, Leanne M.; Thomson, Andrew R.; Birchall, Martin A.; Woolfson, Derek N.
• Is Part Of: Advanced healthcare materials. Volume 3:Issue 9(2014:Sep.)
• Page Start: 1387
• Page End: 1391
• Publication Date: 2014-03-24
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201400065
• Languages: English
• ISSNs: 2192-2640

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adhm201400065-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>α‐Helical peptide hydrogels</bold> are decorated with a cell‐binding peptide motif (RGDS), which is shown to promote adhesion, proliferation, and differentiation of PC12 cells. Gel structure and integrity are maintained after functionalization. This opens possibilities for the bottom‐up design and engineering of complex functional scaffolds for 2D and 3D cell cultures. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh18r68jtv" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>