Lipid‐Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo. Issue 9 (13th March 2014)

• Record Type: Journal Article
• Authors: Dong, Yizhou; Eltoukhy, Ahmed A.; Alabi, Christopher A.; Khan, Omar F.; Veiseh, Omid; Dorkin, J. Robert; Sirirungruang, Sasilada; Yin, Hao; Tang, Benjamin C.; Pelet, Jeisa M.; Chen, Delai; Gu, Zhen; Xue, Yuan; Langer, Robert; Anderson, Daniel G.
• Is Part Of: Advanced healthcare materials. Volume 3:Issue 9(2014:Sep.)
• Page Start: 1392
• Page End: 1397
• Publication Date: 2014-03-13
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201400054
• Languages: English
• ISSNs: 2192-2640

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adhm201400054-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>New lipid‐like nanomaterials</bold> are developed to simultaneously regulate expression of multiple genes. Self‐assembled nanoparticles are capable of efficiently encapsulating pDNA and siRNA. These nanoparticles are shown to induce simultaneous gene expression and silencing both in vitro and in vivo. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh18r68hf8" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>