Peptide‐Directed Spatial Organization of Biomolecules in Dynamic Gradient Scaffolds. Issue 9 (24th February 2014)

• Record Type: Journal Article
• Authors: Chow, Lesley W.; Armgarth, Astrid; St‐Pierre, Jean‐Philippe; Bertazzo, Sergio; Gentilini, Cristina; Aurisicchio, Claudia; McCullen, Seth D.; Steele, Joseph A. M.; Stevens, Molly M.
• Is Part Of: Advanced healthcare materials. Volume 3:Issue 9(2014:Sep.)
• Page Start: 1381
• Page End: 1386
• Publication Date: 2014-02-24
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201400032
• Languages: English
• ISSNs: 2192-2640

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adhm201400032-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Specific binding peptides</bold> are used to spatially organize biomolecule gradients within an electrospun fiber scaffold. Different biomolecule‐binding peptide–polymer conjugates are sequentially co‐electrospun with a fiber‐forming host polymer to generate opposing gradients of peptide functionalization. The binding peptides specifically and non‐covalently guide the spatial arrangement of biomolecules into dynamic gradients within the scaffold, mimicking biological gradients found in native tissues. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh18r68grq" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>