Increase in cyclooxygenase‐2 (COX‐2) expression in keratinocytes and dermal fibroblasts in photoaged skin. (September 2014)

• Record Type: Journal Article
• Authors: Surowiak, Pawel; Gansukh, Tserenchunt; Donizy, Piotr; Halon, Agnieszka; Rybak, Zbigniew
• Is Part Of: Journal of cosmetic dermatology. Volume 13:Number 3(2014:Sep.)
• Page Start: 195
• Page End: 201
• Publication Date: 2014-09
• Subjects: Skin -- Diseases -- Treatment -- Periodicals; Lasers in surgery -- Periodicals; Skin -- Pathophysiology -- Periodicals; Surgery, Plastic -- Periodicals; 616.5
• DOI: 10.1111/jocd.12103
• Languages: English
• ISSNs: 1473-2130

Abstract

<abstract abstract-type="main" id="jocd12103-abs-0001"> <title>Summary</title> <sec id="jocd12103-sec-0001" sec-type="section"> <title>Background</title> <p>Interleukins and NF<italic>κ</italic>‐B are involved in the development of inflammatory reactions. It has been suggested that these proteins are important contributing factors in the process of photoaging of skin. Moreover, interleukins and NF<italic>κ</italic>‐B are known to be capable of inducing expression of cyclooxygenase 2 (COX‐2). Expression of COX‐2 in various populations of skin cells has not been examined in the specific processes of aging.</p> </sec> <sec id="jocd12103-sec-0002" sec-type="section"> <title>Objectives</title> <p>The study aimed at evaluating COX‐2 expression in skin samples originating from patients with chronologically aged and photoaged skin at various stages of skin aging.</p> </sec> <sec id="jocd12103-sec-0003" sec-type="section"> <title>Methods</title> <p>Immunohistochemical analysis of COX‐2 reactivity was conducted on samples originating from 52 women undergoing surgery for reasons other than skin pathology.</p> </sec> <sec id="jocd12103-sec-0004" sec-type="section"> <title>Results</title> <p>Our study demonstrated that COX‐2 expression in keratinocytes and fibroblasts was significantly higher in skin samples affected by photoaging than in samples affected by endogenous aging or obtained from younger individuals.</p> </sec> <sec id="jocd12103-sec-0005" sec-type="section"> <title>Conclusions</title> <p>The results indicate that COX‐2 may be involved in the pathogenesis of the photoaging process. Inhibition of expression or activity of the enzyme may find application in photoaging treatment and/or prophylaxis.</p> </sec> </abstract>