Spatial distribution of theobromine – a low MW drug – in tissues via matrix‐free NALDI‐MS imaging. Issue 9 (25th July 2014)

• Record Type: Journal Article
• Authors: Tata, Alessandra; Montemurro, Chiara; Porcari, Andreia M.; Silva, Kamila C.; Lopes de Faria, José B.; Eberlin, Marcos N.
• Is Part Of: Drug testing and analysis. Volume 6:Issue 9(2014:Sep.)
• Page Start: 949
• Page End: 952
• Publication Date: 2014-07-25
• Subjects: Drugs -- Analysis -- Periodicals; Drug testing -- Periodicals; Chemistry, Forensic -- Periodicals; 615.1901
• DOI: 10.1002/dta.1691
• Languages: English
• ISSNs: 1942-7603

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The ability of nano‐assisted laser desorption‐ionization mass spectrometry imaging (NALDI‐IMS) to provide selective chemical monitoring with appropriate spatial distribution of a low molecular drug in a biological tissue was investigated. NALDI‐IMS is a matrix‐free laser desorption ionization (LDI) protocol based on imprinting of tissue constituents on a nanostructured surface. Using the accumulation of theobromine in rat kidney as a model, NALDI‐IMS was found to provide well‐resolved images of the special distribution of this low molecular weight (MW) drug in tissue. Copyright © 2014 John Wiley &amp; Sons, Ltd.</p> </abstract>