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Copper‐mediated 1, 4‐Conjugate Addition of Boronic Acids and Indoles to Vinylidenebisphosphonate leading to gem‐Bisphosphonates as Potential Antiresorption Bone Drugs. Issue 9 (19th August 2014)
Record Type:
Journal Article
Title:
Copper‐mediated 1, 4‐Conjugate Addition of Boronic Acids and Indoles to Vinylidenebisphosphonate leading to gem‐Bisphosphonates as Potential Antiresorption Bone Drugs. Issue 9 (19th August 2014)
Main Title:
Copper‐mediated 1, 4‐Conjugate Addition of Boronic Acids and Indoles to Vinylidenebisphosphonate leading to gem‐Bisphosphonates as Potential Antiresorption Bone Drugs
<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A wide range of <italic>gem</italic>‐bisphosphonate tetraethyl esters as precursors for bisphosphonic acids, which are potent inhibitors of bone resorption, bearing alkyl, aryl, and indole substituents in the β position were prepared through the Cu<sup>II</sup>‐catalyzed 1, 4‐conjugate addition of boronic acids and indoles to vinylidenebisphosphonate tetraethyl ester.</p> </abstract>