Simple lifestyle recommendations and the outcomes of gestational diabetes. A 2×2 factorial randomized trial. Issue 10 (7th April 2014)

• Record Type: Journal Article
• Authors: Bo, S.; Rosato, R.; Ciccone, G.; Canil, S.; Gambino, R.; Poala, C. B.; Leone, F.; Valla, A.; Grassi, G.; Ghigo, E.; Cassader, M.; Menato, G.
• Is Part Of: Diabetes, obesity & metabolism. Volume 16:Issue 10(2014:Oct.)
• Page Start: 1032
• Page End: 1035
• Publication Date: 2014-04-07
• Subjects: Diabetes -- Periodicals; Obesity -- Periodicals; Metabolism -- Disorders -- Periodicals; Clinical pharmacology -- Periodicals; 616.462
• DOI: 10.1111/dom.12289
• Languages: English
• ISSNs: 1462-8902

Abstract

<abstract abstract-type="main" id="dom12289-abs-0001"> <title>Abstract</title> <p id="dom12289-para-0001">The benefits of exercise and behavioural recommendations in gestational diabetes mellitus (GDM) are controversial. In a randomized trial with a 2×2 factorial design, we examined the effect of exercise and behavioural recommendations on metabolic variables, and maternal/neonatal outcomes in 200 GDM patients. All women were given the same diet: group D received dietary recommendations only; group E was advised to briskly walk 20‐min/day; group B received behavioural dietary recommendations; group BE was prescribed the same as B + E. Dietary habits improved in all groups. In a multivariable regression model, fasting glucose did not change. Exercise, but not behavioural recommendations, was associated with the reduction of postprandial glucose (p &lt; 0001), glycated haemoglobin (HbA1c; p &lt; 0.001), triglycerides (p = 0.02) and C‐reactive protein (CRP; p &lt; 0.001) and reduced any maternal/neonatal complications (OR = 0.50; 95%CI=0.28–0.89;p = 0.02). In GDM patients a simple exercise programme reduced maternal postprandial glucose, HbA1c, CRP, triglycerides and any maternal/neonatal complications, but not fasting glucose values.</p> </abstract>