Effect of Structure and Composition of Copper and Cobalt Complexes with Schiff Base Ligands on their DNA/Protein Interaction and Cytotoxicity1. Issue 11 (17th June 2014)

• Record Type: Journal Article
• Authors: Li, Peng; Niu, Mao‐Fei; Niu, Mei‐Ju; Hong, Min
• Is Part Of: Zeitschrift für anorganische und allgemeine Chemie. Volume 640:Issue 11(2014)
• Page Start: 2238
• Page End: 2246
• Publication Date: 2014-06-17
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry -- Periodicals; 540
• DOI: 10.1002/zaac.201400051
• Languages: English
• ISSNs: 0044-2313

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Four transition metal complexes, namely Cu₂Cl₂(HL¹)₂ (<bold>1</bold>), Co(HL¹)₂ (<bold>2</bold>), Cu(HL²)₂ (<bold>3</bold>), Co(HL²)₃ (<bold>4</bold>) {H₂L¹ = 2‐{[2‐(2‐hydroxy‐ethoxy)‐ethylimino]‐methyl}‐phenol, H₂L² = 3‐{[2‐(2‐hydroxy‐ethoxy)‐ethylimino]‐methyl}‐naphthalen‐2‐ol} were synthesized and characterized by single‐crystal X‐ray diffraction, IR spectroscopy, and elemental analysis. The interactions of these copper and cobalt complexes with calf thymus DNA (CT‐DNA) were studied by absorption and emission titration spectroscopic methods. The interactions of these copper and cobalt complexes with bovine serum albumin (BSA) were also investigated using fluorescence, UV/Vis, and synchronous fluorescence spectroscopy. Further, the <italic>in vitro</italic> cytotoxic effect of the complexes are examined on human colon carcinoma cell lines (HCT‐116) and human lung carcinoma cell line (A549).</p> </abstract>