Nanometric Micelles with Photo‐Triggered Cytotoxicity. (24th June 2014)

• Record Type: Journal Article
• Authors: Anilkumar, Parambath; Gravel, Edmond; Theodorou, Ioanna; Gombert, Karine; Thézé, Benoit; Ducongé, Frédéric; Doris, Eric
• Is Part Of: Advanced functional materials. Volume 24:Number 33(2014)
• Page Start: 5246
• Page End: 5252
• Publication Date: 2014-06-24
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201400840
• Languages: English
• ISSNs: 1616-301X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The development of a photo‐responsive micellar system capable of triggering cell death is reported. Precursors of the micelles are synthesized by connecting a lipophilic chain to a hydrophilic polyethylene glycol via a photo‐labile nitrobenzyl group. The resulting amphiphilic units are self‐assembled in water forming 12 nm micelles that are readily internalized into cells. Upon photo‐irradiation, micelles undergo cleavage and yield a cytotoxic nitrosobenzaldehyde derivative, which significantly inhibits the proliferation of MDA‐MB‐231 cells under standard in vitro conditions.</p> </abstract>