Kinetic Resolution of Oxazinones: Rational Exploration of Chemical Space through the Design of Experiments. Issue 37 (30th July 2014)

• Record Type: Journal Article
• Authors: Renzi, Polyssena; Kronig, Christel; Carlone, Armando; Eröksüz, Serap; Berkessel, Albrecht; Bella, Marco
• Is Part Of: Chemistry. Volume 20:Issue 37(2014)
• Page Start: 11768
• Page End: 11775
• Publication Date: 2014-07-30
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201402380
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The organocatalytic kinetic resolution of 4‐substituted oxazinones has been optimised (selectivity factor <italic>S</italic> up to 98, chiral oxazinone <italic>ee</italic> values up to 99.6 % (<bold>1 a</bold>–<bold>g</bold>) and product <italic>ee</italic> values up to 90 % (<bold>3 a</bold>–<bold>g</bold>)) in a rational way by applying the Design of Experiments (DoE) approach.</p> </abstract>