Organocatalytic Cascade Reactions: Towards the Diversification of Hydroisochromenes and Chromenes through Two Different Activation Modes. Issue 36 (22nd July 2014)

• Record Type: Journal Article
• Authors: Cruz Cruz, David; Mose, Rasmus; Villegas Gómez, Clarisa; Torbensen, Stine V.; Larsen, Martin S.; Jørgensen, Karl Anker
• Is Part Of: Chemistry. Volume 20:Issue 36(2014)
• Page Start: 11331
• Page End: 11335
• Publication Date: 2014-07-22
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201403505
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The organocatalytic enantioselective syntheses of functionalized hydroisochromenes and chromenes by trienamine‐mediated [4+2]‐cycloaddition/nucleophilic ring‐closing and iminium‐ion/aminal‐mediated oxa‐Michael/Michael/nucleophilic ring‐closing with 2‐nitroallylic alcohols are presented. The corresponding cycloadducts, with up to five stereocenters, are formed in good yield and excellent enantioselectivities. The synthetic applications of the obtained products have been demonstrated.</p> </abstract>