High‐Resolution 3D Proton MRI of Hyperpolarized Gas Enabled by Parahydrogen and Rh/TiO2 Heterogeneous Catalyst. Issue 37 (24th June 2014)

• Record Type: Journal Article
• Authors: Kovtunov, Kirill V.; Barskiy, Danila A.; Coffey, Aaron M.; Truong, Milton L.; Salnikov, Oleg G.; Khudorozhkov, Alexander K.; Inozemtseva, Elizaveta A.; Prosvirin, Igor P.; Bukhtiyarov, Valery I.; Waddell, Kevin W.; Chekmenev, Eduard Y.; Koptyug, Igor V.
• Is Part Of: Chemistry. Volume 20:Issue 37(2014)
• Page Start: 11636
• Page End: 11639
• Publication Date: 2014-06-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201403604
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Several supported metal catalysts were synthesized, characterized, and tested in heterogeneous hydrogenation of propene with parahydrogen to maximize nuclear spin hyperpolarization of propane gas using parahydrogen induced polarization (PHIP). The Rh/TiO₂ catalyst with a metal particle size of 1.6 nm was found to be the most active and effective in the pairwise hydrogen addition and robust, demonstrating reproducible results with multiple hydrogenation experiments and stability for ≥1.5 years. 3D ¹H magnetic resonance imaging (MRI) of 1 % hyperpolarized flowing gas with microscale spatial resolution (625×625×625 μm³) and large imaging matrix (128×128×32) was demonstrated by using a preclinical 4.7 T scanner and 17.4 s imaging scan time.</p> </abstract>