Back Cover: Structural Biology of Cisplatin Complexes with Cellular Targets: The Adduct with Human Copper Chaperone Atox1 in Aqueous Solution (Chem. Eur. J. 37/2014). Issue 37 (8th September 2014)

• Record Type: Journal Article
• Authors: Calandrini, Vania; Nguyen, Trung Hai; Arnesano, Fabio; Galliani, Angela; Ippoliti, Emiliano; Carloni, Paolo; Natile, Giovanni
• Is Part Of: Chemistry. Volume 20:Issue 37(2014)
• Page Start: 11956
• Page End: 11956
• Publication Date: 2014-09-08
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201490157
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Hybrid QM/MM simulations</bold> and molecular spectroscopy provide structural insights on cisplatin binding to the copper transporter Atox1 in water solution. A molecular model of the platinated protein is provided. In this model, the Pt atom binds to Cys12 and Cys15 while retaining its two <italic>cis</italic> ammine ligands. The calculated ¹H, ¹³C, and ¹⁵N NMR chemical shifts and CD spectra of this model are in accord with experiment. For the complete story see the Full Paper by P. Carloni et al. on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 11719 ff.</ext-link><boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh12z6kfpn" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>