'From blood to blood': de‐differentiation of hematopoietic progenitors to stem cells. (6th June 2014)

• Record Type: Journal Article
• Authors: Pereira, Carlos‐Filipe; Lemischka, Ihor R; Moore, Kateri
• Is Part Of: EMBO journal. Volume 33:Number 14(2014)
• Page Start: 1511
• Page End: 1513
• Publication Date: 2014-06-06
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.201488980
• Languages: English
• ISSNs: 0261-4189

Abstract

<abstract abstract-type="main" id="embj201488980-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p content-type="executiveSummary">Recent studies have reported that fibroblasts or differentiated pluripotent cells can be reprogrammed with transcription factors (TFs) into cells with hematopoietic potential. A study published in <italic>Cell</italic> now suggests that committed blood precursors may provide a source for blood stem cell transplantation after reprogramming (Riddell <italic>et al</italic>, 2014). The authors report that a combination of eight TFs reprogram murine committed blood progenitors into long‐term engrafting and serially transplantable hematopoietic stem cells with a molecular signature similar to their endogenous counterparts.</p> </abstract>