DOT1L‐HES6 fusion drives androgen independent growth in prostate cancer. Issue 9 (8th July 2014)

• Record Type: Journal Article
• Authors: Annala, Matti; Kivinummi, Kati; Leinonen, Katri; Tuominen, Joonas; Zhang, Wei; Visakorpi, Tapio; Nykter, Matti
• Is Part Of: EMBO molecular medicine. Volume 6:Issue 9(2014:Sep.)
• Page Start: 1121
• Page End: 1123
• Publication Date: 2014-07-08
• Subjects: Molecular biology -- Periodicals; Medical genetics -- Periodicals; Pathology, Molecular -- Periodicals; 616.04205
• DOI: 10.15252/emmm.201404210
• Languages: English
• ISSNs: 1757-4676

Abstract

<abstract abstract-type="graphical" id="emmm201404210-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Evidence is presented for a case of androgen receptor‐negative prostate cancer driven by a <italic>DOT</italic><italic>1</italic><italic>L</italic><italic>‐</italic><italic>HES</italic><italic>6</italic> fusion gene which directly induces overexpression and pathological activation of <italic>HES</italic><italic>6</italic>.<boxed-text content-type="graphic" id="emmm201404210-blkfxd-0001" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh12zp2f4v" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>