No association between type 1 diabetes and genetic variation in vitamin D metabolism genes: a Danish study. Issue 6 (10th December 2013)

• Record Type: Journal Article
• Authors: Thorsen, Steffen U; Mortensen, Henrik B; Carstensen, Bendix; Fenger, Mogens; Thuesen, Betina H; Husemoen, Lotte; Bergholdt, Regine; Brorsson, Caroline; Pociot, Flemming; Linneberg, Allan; Svensson, Jannet
• Is Part Of: Pediatric diabetes. Volume 15:Issue 6(2014:Oct.)
• Page Start: 416
• Page End: 421
• Publication Date: 2013-12-10
• Subjects: Diabetes in children -- Periodicals; 616.462
• DOI: 10.1111/pedi.12105
• Languages: English
• ISSNs: 1399-543X

Abstract

<abstract abstract-type="main" id="pedi12105-abs-0001"> <title>Abstract</title> <sec id="pedi12105-sec-0001" sec-type="section"> <title>Background</title> <p id="pedi12105-para-0001">Vitamin D, certain single nucleotide polymorphisms (SNPs) in the vitamin D‐receptor (VDR) gene and vitamin D metabolism genes have been associated with type 1 diabetes (T1D).</p> </sec> <sec id="pedi12105-sec-0002" sec-type="section"> <title>Objective</title> <p id="pedi12105-para-0002">We wanted to examine if the most widely studied SNPs in genes important for production, transport, and action of vitamin D were associated with T1D or to circulating levels of vitamin D 25‐hydroxyvitamin D [25(OH)D] in a juvenile Danish population.</p> </sec> <sec id="pedi12105-sec-0003" sec-type="section"> <title>Methods</title> <p id="pedi12105-para-0003">We genotyped eight SNPs in five vitamin D metabolism genes in 1467 trios. 25(OH)D status were analyzed in 1803 children (907 patients and 896 siblings).</p> </sec> <sec id="pedi12105-sec-0004" sec-type="section"> <title>Results</title> <p id="pedi12105-para-0004">We did not demonstrate association with T1D for SNPs in the following genes: <italic>CYP27B1, VDR, GC, CYP2R1, DHCR7, and CYP24A1</italic>. Though, variants in the <italic>GC</italic> gene were significantly associated with 25(OH)D levels in the joint model.</p> </sec> <sec id="pedi12105-sec-0005" sec-type="section"> <title>Conclusion</title> <p id="pedi12105-para-0005">Some of the most examined SNPs in vitamin D metabolism genes were not confirmed to be associated with T1D, though 25(OH) levels were associated with variants in the <italic>GC</italic> gene.</p> </sec> </abstract>