Clinical efficacy of intravenous immunoglobulins for the treatment of dermatomyositis skin lesions without muscle disease. (1st August 2013)

• Record Type: Journal Article
• Authors: Bounfour, T.; Bouaziz, J.‐D.; Bézier, M.; Cordoliani, F.; Saussine, A.; Petit, A.; Juillard, C.; Bagot, M.; Rybojad, M.
• Is Part Of: Journal of the European Academy of Dermatology and Venereology. Volume 28:Number 9(2014:Sep.)
• Page Start: 1150
• Page End: 1157
• Publication Date: 2013-08-01
• Subjects: Dermatology -- Periodicals; Sexually transmitted diseases -- Periodicals; 616.5
• DOI: 10.1111/jdv.12223
• Languages: English
• ISSNs: 0926-9959

Abstract

<abstract abstract-type="main" id="jdv12223-abs-0001"> <title>Abstract</title> <sec id="jdv12223-sec-0001" sec-type="section"> <title>Background</title> <p>Treating dermatomyositis (DM) with isolated skin involvement is difficult and inconsistently performed. Intravenous immunoglobulins (IVIg) are recommended for corticoresistant or corticodependant DM, but only a few cases of IVIg use in DM with isolated skin involvement have been reported.</p> </sec> <sec id="jdv12223-sec-0002" sec-type="section"> <title>Design</title> <p>We performed a retrospective monocentric study of 27 patients who were treated with IVIg for severe DM skin lesions (no or minor muscle involvement) after failure of photoprotection and at least one line of treatment.</p> </sec> <sec id="jdv12223-sec-0003" sec-type="section"> <title>Results</title> <p>Nineteen patients (70%) exhibited a major response, four patients exhibited a partial response and four patients exhibited no response, including two patients with grade 3 side effects (headaches). The mean number of IVIg courses was 4.8 (range 1–15). Ten patients (53%) relapsed, with a median time of 6.2 months after the last IVIg course. Six of these patients were successfully treated with a new IVIg course. Muscle disease developed in six patients.</p> </sec> <sec id="jdv12223-sec-0004" sec-type="section"> <title>Conclusion</title> <p>IVIg may be an effective and safe treatment for DM with isolated skin involvement. Relapse occurred frequently, but treatment with a new course of IVIg was successful. Controlled studies are required to confirm these results.</p> </sec> </abstract>