A Multifunctional Nanomicelle for Real‐Time Targeted Imaging and Precise Near‐Infrared Cancer Therapy1. Issue 36 (15th July 2014)

• Record Type: Journal Article
• Authors: Tian, Jiangwei; Ding, Lin; Ju, Huangxian; Yang, Yongchao; Li, Xilan; Shen, Zhen; Zhu, Zhi; Yu, Jun‐Sheng; Yang, Chaoyong James
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 36(2014)
• Page Start: 9544
• Page End: 9549
• Publication Date: 2014-07-15
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201405490
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Simultaneous targeted cancer imaging, therapy and real‐time therapeutic monitoring can prevent over‐ or undertreatment. This work describes the design of a multifunctional nanomicelle for recognition and precise near‐infrared (NIR) cancer therapy. The nanomicelle encapsulates a new pH‐activatable fluorescent probe and a robust NIR photosensitizer, R16FP, and is functionalized with a newly screened cancer‐specific aptamer for targeting viable cancer cells. The fluorescent probe can light up the lysosomes for real‐time imaging. Upon NIR irradiation, R16FP‐mediated generation of reactive oxygen species causes lysosomal destruction and subsequently trigger lysosomal cell death. Meanwhile the fluorescent probe can reflect the cellular status and in situ visualize the treatment process. This protocol can provide molecular information for precise therapy and therapeutic monitoring.</p> </abstract>