Validation of pretreatment neutrophil–lymphocyte ratio as a prognostic factor in a European cohort of patients with upper tract urothelial carcinoma. (27th November 2013)

• Record Type: Journal Article
• Authors: Dalpiaz, Orietta; Ehrlich, Georg C.; Mannweiler, Sebastian; Hernández, Jessica M.Martín; Gerger, Armin; Stojakovic, Tatjana; Pummer, Karl; Zigeuner, Richard; Pichler, Martin; Hutterer, Georg C.
• Is Part Of: BJU international. Volume 114:Number 3(2014:Sep.)
• Page Start: 334
• Page End: 339
• Publication Date: 2013-11-27
• Subjects: Genitourinary organs -- Diseases -- Periodicals; Genitourinary organs -- Surgery -- Periodicals; Urology -- Periodicals; 616.6
• DOI: 10.1111/bju.12441
• Languages: English
• ISSNs: 1464-4096

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="bju12441-sec-0001" sec-type="section"> <title>Objective</title> <p> <list id="bju12441-list-0001" list-type="bullet"> <list-item> <p>To investigate the potential prognostic significance of the neutrophil–lymphocyte ratio (NLR) in a large European cohort of patients with upper urinary tract urothelial cell carcinoma (UUT‐UCC).</p> </list-item> </list> </p> </sec> <sec id="bju12441-sec-0002" sec-type="section"> <title>Patients and Methods</title> <p> <list id="bju12441-list-0002" list-type="bullet"> <list-item> <p>We retrospectively evaluated data from 202 consecutive patients with non‐metastatic upper urinary tract urothelial cell carcinoma (UUT‐UCC), who underwent surgery between 1990 and 2012 at a single tertiary academic centre.</p> </list-item> <list-item> <p>Patients' cancer‐specific survival (CSS) and overall survival (OS) were assessed using the Kaplan–Meier method.</p> </list-item> <list-item> <p>To evaluate the independent prognostic significance of the NLR, multivariate proportional Cox regression models were applied for both endpoints.</p> </list-item> </list> </p> </sec> <sec id="bju12441-sec-0003" sec-type="section"> <title>Results</title> <p> <list id="bju12441-list-0003" list-type="bullet"> <list-item> <p>A higher NLR was significantly associated with shorter CSS (<italic>P</italic> = 0.002, log‐rank test), as well as with shorter OS (<italic>P</italic> < 0.001, log‐rank test).</p> </list-item> <list-item> <p>Multivariate analysis identified a high NLR as an independent prognostic factor for patients' CSS (hazard ratio 2.72, 95% CI 1.25–5.93, <italic>P</italic> = 0.012), and OS (hazard ratio 2.48, 95% CI 1.31–4.70, <italic>P</italic> = 0.005).</p> </list-item> </list> </p> </sec> <sec id="bju12441-sec-0004" sec-type="section"> <title>Conclusions</title> <p> <list id="bju12441-list-0004" list-type="bullet"> <list-item> <p>In the present cohort, patients with a high preoperative NLR had higher cancer‐specific and overall mortality after radical surgery for UUT‐UCC, compared with those with a low preoperative NLR.</p> </list-item> <list-item> <p>This easily identifiable laboratory measure should be considered as an additional prognostic factor in UUT‐UCC in future.</p> </list-item> </list> </p> </sec> </abstract>