Adjuvant systemic chemotherapy with or without bevacizumab in patients with resected pulmonary metastases from colorectal cancer. Issue 5 (September 2014)

• Record Type: Journal Article
• Authors: Turan, Nedim; Benekli, Mustafa; Dane, Faysal; Unal, Olcun Umit; Kara, Hasan Volkan; Koca, Dogan; Balvan, Ozlem; Eren, Tulay; Tastekin, Didem; Helvaci, Kaan; Berk, Veli; Demirci, Umut; Ozturk, Selcuk Cemil; Dogan, Erkan; Cetin, Bulent; Kucukoner, Mehmet; Tonyali, Onder; Tufan, Gulnihal; Oztop, Ilhan; Gumus, Mahmut; Coskun, Ugur; Uner, Aytug; Ozet, Ahmet; Buyukberber, Suleyman; for the Anatolian Society of Medical Oncology (ASMO)
• Is Part Of: Thoracic cancer. Volume 5:Issue 5(2014)
• Page Start: 398
• Page End: 404
• Publication Date: 2014-09
• Subjects: Chest -- Cancer -- Periodicals; Chest -- Cancer -- Treatment -- Periodicals; Chest -- Surgery -- Periodicals; 616.99494005
• DOI: 10.1111/1759-7714.12107
• Languages: English
• ISSNs: 1759-7706

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="tca12107-sec-0001" sec-type="section"> <title>Introduction</title> <p>We investigated the impact of modern chemotherapy regimens and bevacizumab following pulmonary metastasectomy (PM) from metastatic colorectal cancer (CRC).</p> </sec> <sec id="tca12107-sec-0002" sec-type="section"> <title>Methods</title> <p>A total of 122 consecutive patients who were curatively resected for pulmonary metastases of CRC in twelve oncology centers were retrospectively analysed between January 2000 and April 2012.</p> </sec> <sec id="tca12107-sec-0003" sec-type="section"> <title>Results</title> <p>Of 122 patients, 14 did not receive any treatment following PM. The remaining 108 patients received fluoropyrimidine‐based (<italic>n</italic> = 12), irinotecan‐based (<italic>n</italic> = 56) and oxaliplatin‐based (<italic>n</italic> = 40) chemotherapy combinations. Among these, 52 patients received bevacizumab (BEV) while 56 did not (NoBEV). Median recurrence‐free survival (RFS) was 17 months and median overall survival (OS) has not been reached at a median follow‐up of 25 months after PM. Three and five‐year OS rates were 66% and 53%, respectively. RFS and OS were similar, irrespective of the chemotherapy regimen or BEV use. Positive pulmonary margin, KRAS mutation status, and previous liver metastasectomy were negative independent prognostic factors for RFS, while pathologically confirmed thoracic lymph node involvement was the only negative independent prognostic for OS in multivariate analysis.</p> </sec> <sec id="tca12107-sec-0004" sec-type="section"> <title>Conclusions</title> <p>No significant RFS or OS difference was observed in respect to chemotherapy regimens with or without BEV in patients with pulmonary metastases of CRC following curative resection.</p> </sec> </abstract>