Cover Picture: Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry (Angew. Chem. Int. Ed. 36/2014). Issue 36 (1st September 2014)

• Record Type: Journal Article
• Authors: Dong, Jiajia; Krasnova, Larissa; Finn, M. G.; Sharpless, K. Barry
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 36(2014)
• Page Start: 9391
• Page End: 9391
• Publication Date: 2014-09-01
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201401157
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic> <bold>A completely new click chemistry</bold> </italic> is described by K. B. Sharpless, M. G. Finn, and co‐workers in their Review on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 9430 ff.</ext-link> The robust bond between S^VI and F atoms (such as in the gas SO₂F₂ and Michael acceptor HCCHSO₂F) can be specifically activated by proton (often in the form of the bifluoride ion, HF₂⁻) or silicon centers (e.g. an aryl silyl ether) to create S–heteroatom linkages of surprising stability. Applications of this click 2.0 method to the synthesis of small molecules or polymers (see the Communication by K. B. Sharpless, V. V. Fokin et al. on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 9466 ff.</ext-link>), and the modification of biomolecules—each represented at the periphery of the image—are discussed.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh12z671wx" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>