N‐Heterocyclic‐Carbene‐Catalyzed Synthesis of 2‐Aryl Indoles1. (14th July 2014)

• Record Type: Journal Article
• Authors: Hovey, M. Todd; Check, Christopher T.; Sipher, Alexandra F.; Scheidt, Karl A.
• Is Part Of: Angewandte Chemie. Volume 126:Number 36(2014)
• Page Start: 9757
• Page End: 9761
• Publication Date: 2014-07-14
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201405035
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A convergent and efficient transition‐metal‐free catalytic synthesis of 2‐aryl‐indoles has been developed. The interception of a highly reactive and transient aza‐<italic>ortho</italic>‐quinone methide by an acyl anion equivalent generated through N‐hetereocyclic carbene catalysis is central to this successful strategy. High yields and a wide scope as well as the streamlined synthesis of a kinase inhibitor are reported.</p> </abstract>