A Simple, Efficient One‐Pot Synthesis of 2‐Isoxazoline Derivatives and their Antimicrobial Activity. (18th April 2014)

• Record Type: Journal Article
• Authors: Kiran Kumar, A. B. V.; Uma Ravi Sankar, A.; Kim, Sang Ho
• Is Part Of: Journal of heterocyclic chemistry. Volume 51:Number 1(2014:Jan.)
• Page Start: E146
• Page End: E151
• Publication Date: 2014-04-18
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.1912
• Languages: English
• ISSNs: 0022-152X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Synthesis of substituted 2‐isoxazolines derivatives with sulfone functional groups was accomplished by <named-content content-type="reactionType" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">1, 3‐dipolar cycloaddition reaction</named-content>. The 1, 3‐dipolar nitrile oxides generated <italic>in situ</italic> by reacting α‐formaldoximes with <italic>N</italic>‐bromosuccinimide in the presence of triethylamine on reaction with activated alkenes in toluene at room temperature afford the corresponding 2‐isoxazolines in high yields. All the 2‐isoxazoline derivatives were assayed for their antibacterial activities against <italic>Staphylococcus aureus</italic>, <italic>Bacillus cereus</italic>, <italic>Escherichia coli</italic>, and <italic>Pseudomonas aeruginosa</italic> and antifungal activities against <italic>Aspergillus niger</italic> and <italic>Candida albicans</italic>. Most of the compounds showed good antibacterial and antifungal activities.</p> </abstract>