Infants 1–90 Days Old Hospitalized With Human Rhinovirus Infection. Issue 5 (19th March 2014)

• Record Type: Journal Article
• Authors: Bender, Jeffrey M.; Taylor, Charla S.; Cumpio, Joven; Novak, Susan M.; She, Rosemary C.; Steinberg, Evan A.; Marlowe, Elizabeth M.
• Is Part Of: Journal of clinical laboratory analysis. Volume 28:Issue 5(2014:Sep.)
• Page Start: 349
• Page End: 352
• Publication Date: 2014-03-19
• Subjects: Diagnosis, Laboratory -- Periodicals; Medical laboratory technology -- Periodicals; 616
• DOI: 10.1002/jcla.21692
• Languages: English
• ISSNs: 0887-8013

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jcla21692-sec-0010" sec-type="section"> <title>Background</title> <p>Human rhinovirus (HRV) is a common cause of respiratory illness in children. The impact of HRV infection on 1‐ to 90‐day‐old infants is unclear. We hypothesized that HRV infection would be clinically similar to respiratory syncytial virus (RSV) infection in the hospitalized infants.</p> </sec> <sec id="jcla21692-sec-0020" sec-type="section"> <title>Methods</title> <p>We conducted a retrospective study of hospitalized infants, who were 1–90 days old, with HRV or RSV within the Southern California Kaiser Permanente network over a 1‐year period (August 2010 to October 2011).</p> </sec> <sec id="jcla21692-sec-0030" sec-type="section"> <title>Results</title> <p>We identified 245 hospitalized infants who underwent respiratory virus testing. HRV was found in 52 infants (21%) compared to 79 infants (32%) with RSV (<italic>P</italic> = 0.008). Infants with HRV infection experienced longer hospital stays compared to those with RSV (median length of stay 4 days vs. 3 days, <italic>P</italic> = 0.009) and had fewer short hospital stays ≤3 days (<italic>P</italic> = 0.029). There was a trend in infants with HRV infection to be younger (<italic>P</italic> = 0.071) and have more fevers (<italic>P</italic> = 0.052).</p> </sec> <sec id="jcla21692-sec-0040" sec-type="section"> <title>Conclusions</title> <p>Recent advances in diagnostics allow for identification of a broad range of viral pathogens in infants. Compared to RSV, HRV was associated with longer hospital stays. Additional studies and improved, more specific testing, methods are needed to further define the effects of HRV infection in infants 1–90 days old.</p> </sec> </abstract>