Estimating the risk of squamous cell cancer induction in skin following nonlinear optical imaging. Issue 7 (8th February 2013)

• Record Type: Journal Article
• Authors: Thomas, Giju; Nadiarnykh, Oleg; van Voskuilen, Johan; Hoy, Christopher L.; Gerritsen, Hans C.; Sterenborg, Henricus J. C. M.
• Is Part Of: Journal of biophotonics. Volume 7:Issue 7(2014)
• Page Start: 492
• Page End: 505
• Publication Date: 2013-02-08
• Subjects: Photonics -- Periodicals; Optical materials -- Periodicals; Optics -- Periodicals; Medical instruments and apparatus -- Periodicals; 621.3605
• DOI: 10.1002/jbio.201200207
• Languages: English
• ISSNs: 1864-063X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>High power femto‐second (fs) laser pulses used for <italic>in‐vivo</italic> nonlinear optical (NLO) imaging can form cyclobutane pyrimidine dimers (CPD) in DNA, which may lead to carcinogenesis via subsequent mutations. Since UV radiation from routine sun exposure is the primary source of CPD lesions, we evaluated the risk of CPD‐related squamous cell carcinoma (SCC) in human skin due to NLO imaging relative to that from sun exposure. We developed a unique cancer risk model expanding previously published estimation of risk from exposure to continuous wave (CW) laser. This new model showed that the increase in CPD‐related SCC in skin from NLO imaging is negligible above that due to regular sun exposure. (© 2014 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)</p> </abstract>