Hyperbranched Supramolecular Polymer of Tris(permethyl‐β‐cyclodextrin)s with Porphyrins: Characterization and Magnetic Resonance Imaging. Issue 8 (22nd April 2014)

• Record Type: Journal Article
• Authors: Sun, Mo; Zhang, Hengyi; Hu, Xinyue; Liu, Bowen; Liu, Yu
• Is Part Of: Chinese journal of chemistry. Volume 32:Issue 8(2014:Aug.)
• Page Start: 771
• Page End: 776
• Publication Date: 2014-04-22
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cjoc.201400090
• Languages: English
• ISSNs: 1001-604X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A hyperbranched supramolecular polymer (HSP) is constructed based on the intermolecular inclusion complexation of bridged tris(permethyl‐<italic>β</italic>‐cyclodextrin) with Mn^III‐porphyrin bearing poly(ethylene glycol) (PEG) side chains (Mn^III‐TPP), and characterized by UV/vis absorption spectroscopy, isothermal titration calorimetry (ITC), NMR, dynamic light scattering (DLS), atomic force microscopy (AFM) and transmission electron microscopy (TEM), respectively. The presence of permethyl‐<italic>β</italic>‐cyclodextrin can stabilize the low‐valent Mn^II‐TPP.<italic> In vitro</italic> cell experiment indicates that this HSP has no remarkable cellular toxicity against NIH 3T3 cells. <italic>In vitro</italic> MR imaging experiment indicates a slightly increased <italic>T</italic>₁ relaxivity for this HSP compared to that for the linear supramolecular polymer.</p> </abstract>