Peripheral biomarkers of oxidative stress and their limited potential in evaluation of clinical features of Huntington's patients. (September 2014)

• Record Type: Journal Article
• Authors: Ciancarelli, Irene; De Amicis, Daniela; Di Massimo, Caterina; Di Scanno, Carla; Pistarini, Caterina; D'Orazio, Nicolantonio; Tozzi Ciancarelli, Maria Giuliana
• Is Part Of: Biomarkers. Volume 19:Number 6(2014)
• Page Start: 452
• Page End: 456
• Publication Date: 2014-09
• Subjects: Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2014.935955
• Languages: English
• ISSNs: 1354-750X

Abstract

<abstract> <title>Abstract</title> <p> <italic>Context</italic>: Peripheral oxidative biomarkers could be useful for monitoring clinical features of Huntington's disease (HD).</p> <p> <italic>Materials and methods</italic>: Cu/Zn-superoxide dismutase (Cu/Zn-SOD), neuron-specific enolase (NSE) and 8-hydroxy-2′-deoxyguanosine (8-oxoGua) serum levels were analysed in 18 HD patients and 10 controls. Clinical measures were recorded from each HD patients.</p> <p> <italic>Results</italic>: Cu/Zn-SOD, NSE and 8-oxoGua values were higher in HD patients than in controls. Cu/Zn-SOD and NSE correlated positively. No correlation was observed between the biomarkers analysed and the clinical measures assessed.</p> <p> <italic>Discussion and conclusion</italic>: Serum oxidative biomarkers could express the neuronal oxidative processes going on in HD patients but are inadequate to evaluate clinical features of the disease.</p> </abstract>