Exploring the in situ Utilization of Cyclic Imine Intermediates Generated by Isocyanoacetate Cycloaddition: Convergent Assembly of cis‐3a, 8a‐Hexahydropyrrolo[2, 3‐b]indole Scaffolds. Issue 11 (31st July 2014)

• Record Type: Journal Article
• Authors: Huang, Lin; Cheng, Hengguang; Zhang, Runmei; Wang, Min; Xie, Chunsong
• Is Part Of: Advanced synthesis & catalysis. Volume 356:Issue 11/12(2014)
• Page Start: 2477
• Page End: 2484
• Publication Date: 2014-07-31
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201400376
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Under copper(I) or silver(I)/base cocatalysis conditions, transient 2<italic>H</italic>‐pyrroline intermediates generated by the cycloaddition of isocyanoacetates and olefins can be <italic>in situ</italic> subjected to further transformations. A strategically novel, convergent, mild, efficient, general and atom‐economic access to <italic>cis</italic>‐3a, 8a‐hexahydropyrrolo[2, 3‐<italic>b</italic>]indoles, which are core scaffolds in many biologically important natural products, has been developed based on this concept.</p> <p> <boxed-text content-type="graphic" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh11pkcd10" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> </abstract>