Neutralized Nanoparticle Composed of SS‐Cleavable and pH‐Activated Lipid‐Like Material as a Long‐Lasting and Liver‐Specific Gene Delivery System. Issue 8 (26th March 2014) - Ukawa, Masami
Abstract Charge‐neutralized lipid envelope‐type nanoparticles formed with SS‐cleavable and pH‐activated lipid‐like materials (ssPalm) accumulate rapidly in the liver without forming aggregates in the blood circulation, and result in a liver‐specific gene expression for a long duration (>2 weeks) with neither immunological responses nor hepatotoxicity after intraveneous administration, when it carries pDNA free from CpG‐motifs.