Impact of ethnicity on human umbilical cord blood banking: a systematic review. Issue 8 (4th April 2014)

• Record Type: Journal Article
• Authors: Akyurekli, Celine; Chan, Joshua Y.S.; Elmoazzen, Heidi; Tay, Jason; Allan, David S.
• Is Part Of: Transfusion. Volume 54:Issue 8(2014)
• Page Start: 2122
• Page End: 2127
• Publication Date: 2014-04-04
• Subjects: Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; Blood Group Antigens -- Periodicals; Blood Preservation -- Periodicals; Blood Transfusion -- Periodicals; 615
• DOI: 10.1111/trf.12630
• Languages: English
• ISSNs: 0041-1132

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="trf12630-sec-0001" sec-type="section"> <title>Background</title> <p>How ethnicity impacts characteristics of umbilical cord blood collected by cord blood banks remains unclear.</p> </sec> <sec id="trf12630-sec-0002" sec-type="section"> <title>Study Design and Methods</title> <p>After a systematic search, we identified 11 studies for analysis that reported on various variables of collected cord blood units.</p> </sec> <sec id="trf12630-sec-0003" sec-type="section"> <title>Results</title> <p>Non‐Caucasian ethnicity of the cord blood donor was associated with a higher risk of failing to meet banking criteria, lower cord blood volume, reduced total nucleated cell count, fewer CD34+ cells, and reduced colony‐forming units.</p> </sec> <sec id="trf12630-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Non‐Caucasian ethnicity is associated with reductions in hematopoietic measures of collected cord blood units. Public banking efforts will have to balance issues related to building ethnic diversity within the bank and maintaining the characteristics of banked units that remain desirable by transplant centers.</p> </sec> </abstract>