A correlation between severe haemolytic disease of the fetus and newborn and maternal ABO blood group. Issue 4 (28th June 2014)

• Record Type: Journal Article
• Authors: Doyle, B.; Quigley, J.; Lambert, M.; Crumlish, J.; Walsh, C.; McParland, P.; Culliton, M.; Murphy, K.; Fitzgerald, J.
• Is Part Of: Transfusion medicine. Volume 24:Issue 4(2014)
• Page Start: 239
• Page End: 243
• Publication Date: 2014-06-28
• Subjects: Blood -- Transfusion -- Periodicals; 615.39
• DOI: 10.1111/tme.12132
• Languages: English
• ISSNs: 0958-7578

Abstract

<abstract abstract-type="main" id="tme12132-abs-0001"> <title>SUMMARY</title> <sec id="tme12132-sec-0001" sec-type="section"> <title>Objective</title> <p id="tme12132-para-0001">To analyse anti‐D quantification levels and frequency of intrauterine transfusion (IUT), per maternal ABO blood group.</p> </sec> <sec id="tme12132-sec-0002" sec-type="section"> <title>Background</title> <p id="tme12132-para-0002">Maternally derived red cell allo‐antibodies can target fetal red cell antigens <italic>in utero</italic> leading to haemolytic disease and fetal anaemia. When a clinically significant allo‐antibody is formed the priority is ascertaining the risk to the fetus and maternal ABO blood groups are not considered relevant.</p> </sec> <sec id="tme12132-sec-0003" sec-type="section"> <title>Materials and methods</title> <p id="tme12132-para-0003">This was a 10‐year retrospective, observational study carried out on women referred for anti‐D quantification (<italic>n</italic> = 1106), and women whose fetuses required an IUT to treat fetal anaemia (<italic>n</italic> = 62) due to anti‐D, in the Republic of Ireland.</p> </sec> <sec id="tme12132-sec-0004" sec-type="section"> <title>Results</title> <p id="tme12132-para-0004">Relative to the overall incidence of RhD allo‐immunisation by blood group, women of blood group A were more likely to require IUT compared with those who were blood group O (<italic>P</italic> = 0·002).</p> </sec> <sec id="tme12132-sec-0005" sec-type="section"> <title>Conclusion</title> <p id="tme12132-para-0005">It is known that ABO feto‐maternal compatibility can influence the incidence and level of red cell allo‐antibodies in pregnancy; however, it does not account for the significantly high rate of severe haemolytic disease requiring IUT seen in blood group A women.</p> </sec> </abstract>