Coenzyme Q10 supplementation in infertile men with low‐grade varicocele: an open, uncontrolled pilot study. (22nd August 2013)

• Record Type: Journal Article
• Authors: Festa, R.; Giacchi, E.; Raimondo, S.; Tiano, L.; Zuccarelli, P.; Silvestrini, A.; Meucci, E.; Littarru, G. P.; Mancini, A.
• Is Part Of: Andrologia. Volume 46:Number 7(2014)
• Page Start: 805
• Page End: 807
• Publication Date: 2013-08-22
• Subjects: Andrology -- Periodicals; Infertility, Male -- Periodicals; 616.69
• DOI: 10.1111/and.12152
• Languages: English
• ISSNs: 0303-4569

Abstract

<abstract abstract-type="main" id="and12152-abs-0001"> <title>Summary</title> <p>Many conditions associated with male infertility are inducers of oxidative stress, including varicocele. Antioxidants, such as coenzyme Q10, may be useful in this case. To evaluate the antioxidant capacity of seminal plasma of infertile men with varicocele before and after an oral supplementation with coenzyme Q₁₀, 38 patients were recruited from a pilot clinical trial. A standard semen analysis was also performed at baseline and 3 months after an oral supplementation with exogenous coenzyme Q₁₀ 100 mg per die. Seminal plasma antioxidant capacity was measured using a spectroscopic method. Coenzyme Q₁₀ therapy improved semen parameters and antioxidant status. This study highlights the importance of oxidative stress in the pathogenesis of male infertility, namely in varicocele, and strengthens the possibility of the usefulness of the antioxidant therapy.</p> </abstract>