Autonomic dysfunction assessed by EZSCAN and subclinical atherosclerosisEZSCAN 检测自主神经功能紊乱与亚临床动脉粥样硬化相关性研究. (27th March 2014)

• Record Type: Journal Article
• Authors: Sun, Jichao; Zhang, Yinfei; Xu, Baihui; Lv, Xiaofei; Ding, Lin; Chen, Ying; Sun, Wanwan; Lu, Jieli; Xu, Min; Bi, Yufang; Ning, Guang
• Is Part Of: Journal of diabetes. Volume 6:Number 5(2014)
• Page Start: 409
• Page End: 416
• Publication Date: 2014-03-27
• Subjects: Diabetes -- Periodicals; 618.3646005
• DOI: 10.1111/1753-0407.12135
• Languages: English
• ISSNs: 1753-0393

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jdb12135-sec-0001" sec-type="section"> <title>Background</title> <p>The present study aimed to explore the association between autonomic dysfunction and measurements of atherosclerosis in a middle‐aged and elderly Chinese population.</p> </sec> <sec id="jdb12135-sec-0002" sec-type="section"> <title>Methods</title> <p>A population‐based cross‐sectional study was performed in Shanghai, China, from March to August 2010, with 5076 participants included in the analysis. Autonomic function was assessed by a novel EZSCAN test based on sudomotor function analysis. Carotid intima–media thickness (CIMT) was measured using B‐mode ultrasonography and brachial–ankle pulse wave velocity (ba‐PWV) was measured using an autonomic device. Participants were divided into three groups based on EZSCAN values: Group 1: EZSCAN 0–24; Group 2, EZSCAN 25–49; and Group 3, EZSCAN 50–100. These groups denoted autonomic dysfunction risk groups as follows: no risk, moderate risk and high risk, respectively.</p> </sec> <sec id="jdb12135-sec-0003" sec-type="section"> <title>Results</title> <p>The prevalence of elevated CIMT and ba‐PWV increased markedly with increasing EZSCAN values (elevated CIMT 7.4%, 17.5%, and 29.7%, elevated ba‐PWV 3.2%, 19.7%, and 36.5%, in Groups 1, 2, and 3, respectively; both <italic>P</italic><sub>trend</sub> < 0.0001). Logistic regressions revealed that EZSCAN values ≥50 were associated with a non‐significantly higher risk of elevated CIMT (odds ratio [OR] = 1.43; 95% confidence interval [CI] 0.98–2.07) and a significantly higher risk of elevated ba‐PWV (OR = 2.16; 95% CI 1.25–3.71) compared with EZSCAN values <25, after controlling for conventional risk factors.</p> </sec> <sec id="jdb12135-sec-0004" sec-type="section"> <title>Conclusion</title> <p>A higher EZSCAN value (≥50), an index of high autonomic dysfunction risk, was associated with an increased risk of elevated ba‐PWV and CIMT. Such associations were partially explained by traditional atherosclerotic risk factors.</p> </sec> </abstract>