Aeromonas salmonicida subsp. salmonicida in the light of its type‐three secretion system. Issue 5 (7th October 2013)

• Record Type: Journal Article
• Authors: Vanden Bergh, Philippe; Frey, Joachim
• Is Part Of: Microbial biotechnology. Volume 7:Issue 5(2014:Sep.)
• Page Start: 381
• Page End: 400
• Publication Date: 2013-10-07
• Subjects: Microbial biotechnology -- Periodicals; Biotechnology; Microbiology; 660.62
• DOI: 10.1111/1751-7915.12091
• Languages: English
• ISSNs: 1751-7915

Abstract

<abstract abstract-type="main"> <title>Summary</title> <p> <italic>Aeromonas salmonicida</italic> subsp. <italic>salmonicida</italic> is an important pathogen in salmonid aquaculture and is responsible for the typical furunculosis. The type‐three secretion system (T3SS) is a major virulence system. In this work, we review structure and function of this highly sophisticated nanosyringe in <italic>A. salmonicida</italic>. Based on the literature as well as personal experimental observations, we document the genetic (re)organization, expression regulation, anatomy, putative functional origin and roles in the infectious process of this T3SS. We propose a model of pathogenesis where <italic>A. salmonicida</italic> induces a temporary immunosuppression state in fish in order to acquire free access to host tissues. Finally, we highlight putative important therapeutic and vaccine strategies to prevent furunculosis of salmonid fish.</p> </abstract>