Natural D‐glucose as a biodegradable MRI relaxation agent. Issue 3 (27th June 2014)

• Record Type: Journal Article
• Authors: Yadav, Nirbhay N.; Xu, Jiadi; Bar‐Shir, Amnon; Qin, Qin; Chan, Kannie W.Y.; Grgac, Ksenija; Li, Wenbo; McMahon, Michael T.; van Zijl, Peter C.M.
• Is Part Of: Magnetic resonance in medicine. Volume 72:Issue 3(2014:Sep.)
• Page Start: 823
• Page End: 828
• Publication Date: 2014-06-27
• Subjects: Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.25329
• Languages: English
• ISSNs: 0740-3194

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mrm25329-sec-0101" sec-type="section"> <title>Purpose</title> <p>Demonstrate applicability of natural D‐glucose as a <italic>T</italic><sub>2</sub> MRI contrast agent.</p> </sec> <sec id="mrm25329-sec-0102" sec-type="section"> <title>Methods</title> <p>D‐glucose solutions were prepared at multiple concentrations and variable pH. The relaxation rate (<italic>R</italic><sub>2</sub> = 1/<italic>T</italic><sub>2</sub>) was measured at 3, 7, and 11.7 T. Additional experiments were performed on blood at 11.7 T. Also, a mouse was infused with D‐glucose (3.0 mmol/kg) and dynamic <italic>T</italic><sub>2</sub> weighted images of the abdomen acquired.</p> </sec> <sec id="mrm25329-sec-0103" sec-type="section"> <title>Results</title> <p>The transverse relaxation rate depended strongly on glucose concentration and solution pH. A maximum change in <italic>R</italic><sub>2</sub> was observed around physiological pH (pH 6.8‐7.8). The transverse relaxivities at 22°C (pH 7.3) were 0.021, 0.060, and 0.077 s<sup>−1</sup>mM<sup>−1</sup> at 3.0, 7.0, and 11.7 T, respectively. These values showed good agreement with expected values from the Swift‐Connick equation. There was no significant dependence on glucose concentration or pH for <italic>T</italic><sub>1</sub> and the diffusion coefficient for these solutions. The transverse relaxivity in blood at 11.7 T was 0.09 s<sup>−1</sup>mM<sup>−1</sup>. The dynamic in vivo experiment showed a 10% drop in signal intensity after glucose infusion followed by recovery of the signal intensity after about 50–100 s.</p> </sec> <sec id="mrm25329-sec-0104" sec-type="section"> <title>Conclusion</title> <p>Glucose can be used as a <italic>T</italic><sub>2</sub> contrast agent for MRI at concentrations that are already approved for human use. Magn Reson Med 72:823–828, 2014. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>