Absolute magnetic susceptibility of rat brain tissue. Issue 3 (7th October 2013)

• Record Type: Journal Article
• Authors: Peprah, Marcus K.; Astary, Garrett W.; Mareci, Thomas H.; Meisel, Mark W.
• Is Part Of: Magnetic resonance in medicine. Volume 72:Issue 3(2014:Sep.)
• Page Start: 876
• Page End: 879
• Publication Date: 2013-10-07
• Subjects: Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.24965
• Languages: English
• ISSNs: 0740-3194

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mrm24965-sec-0001" sec-type="section"> <title>Purpose</title> <p>This study was performed to test the commonly held hypothesis that the absolute magnetic susceptibility of brain tissue is close to that of water since water accounts for over 50% of the tissue composition. In addition, the absolute value of susceptibility of brain tissue is needed for the development of materials that are implanted into or in close proximity to tissue.</p> </sec> <sec id="mrm24965-sec-0002" sec-type="section"> <title>Methods</title> <p>The absolute magnetic susceptibilities of different sections of rat brain, which were exsanguinated and perfusion‐fixed, have been measured in a commercial superconducting quantum interference device magnetometer operating in fields up to 7T.</p> </sec> <sec id="mrm24965-sec-0003" sec-type="section"> <title>Results</title> <p>The average measured values ranged from −(9.51 ± 0.01) × 10<sup>−6</sup> for the cerebellum to −(8.99 ± 0.01) × 10<sup>−6</sup> for a mixture of hippocampus, corpus callosum, and striatum. The time evolution of the samples was also studied, and deviations of <1% were observed after 4 weeks, although this trend was sample‐specific.</p> </sec> <sec id="mrm24965-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The measured susceptibilities are close to the value measured for high‐performance liquid chromatography H<sub>2</sub>O and depend on the amount of gray and white matter regions present in the samples. Magn Reson Med 72:876–879, 2014. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>