Contrast enhanced MR venography with gadofosveset trisodium: Evaluation of the intracranial and extracranial venous system. Issue 3 (22nd November 2013)

• Record Type: Journal Article
• Authors: Kramer, Larry A.; Cohen, Alan M.; Hasan, Khader M.; Heimbigner, Jared H.; Barreto, Andrew D.; Brod, Staley A.; Narayana, Ponnada A.; Wolinsky, Jerry S.
• Is Part Of: Journal of magnetic resonance imaging. Volume 40:Issue 3(2014)
• Page Start: 630
• Page End: 640
• Publication Date: 2013-11-22
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24409
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24409-sec-0001" sec-type="section"> <title>Purpose</title> <p>To demonstrate the efficacy of contrast enhanced magnetic resonance venography (CEMRV) using gadofosveset trisodium in the comprehensive evaluation of the intracranial and extracranial venous system.</p> </sec> <sec id="jmri24409-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Temporal signal decay, in‐plane saturation and flow artifacts were assessed in an institutional review board approved, HIPAA compliant CEMRV study of 99 subjects. In a 39 subject subset, percent diameter narrowing of the internal jugular (IJ), brachiocephalic and azygous veins were coded according to the following ordinal grades for both catheter venography (CV) and CEMRV: grade 0 ≤ 50%, grade 1 >50% and ≤ 75%, grade 2 >75% and <100% and grade 3 = 100% and compared with pressure gradient measurements obtained during CV.</p> </sec> <sec id="jmri24409-sec-0003" sec-type="section"> <title>Results</title> <p>There was no significant signal decay, in‐plane saturation or flow artifacts identified on CEMRV or hemodynamically significant pressure gradients identified on CV. All brachiocephalic and azygous veins had matched grade 0 narrowing on both modalities. Discrepancy between modalities occurred in the IJ veins at the level of thyroid gland where 15% of IJ veins had CEMRV grade ≥ 1 narrowing compared with 4% for CV or below the thyroid gland where 5% of IJ veins had CEMRV grade ≥ 1 narrowing compared with 20% for CV. There was fair agreement (κ = 0.24) between modalities for grade of narrowing in the combined data set of all coded veins.</p> </sec> <sec id="jmri24409-sec-0004" sec-type="section"> <title>Conclusion</title> <p>CEMRV using gadofosveset trisodium is accurate in the evaluation of the venous system. <bold>J. Magn. Reson. Imaging 2014;40:630–640</bold>. © <bold>2013 Wiley Periodicals, Inc</bold>.</p> </sec> </abstract>