Inflammatory vocal fold lesions associated with angiogenesis inhibition. Issue 9 (10th March 2014)

• Record Type: Journal Article
• Authors: Hartl, Dana M.; Saavedra, Erika; Hollebecque, Antoine; Bahleda, Rastilav; Bosq, Jacques; Massard, Christophe; Soria, Jean‐Charles; Andersen, Peter
• Is Part Of: Head & neck. Volume 36:Issue 9(2014:Sep.)
• Page Start: E81
• Page End: E85
• Publication Date: 2014-03-10
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.23550
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="hed23550-sec-0001" sec-type="section"> <title>Background</title> <p>The vascular side effects of angiogenesis inhibitors are well known, but laryngeal effects are not widely reported. We report the first 5 cases, to our knowledge, of objective vocal fold lesions attributable to these therapies.</p> </sec> <sec id="hed23550-sec-0002" sec-type="section"> <title>Methods</title> <p>Four patients treated with bevacizumab‐paclitaxel or bevacizumab for metastatic breast or lung cancer and 1 patient treated with a pan‐fibroblast growth factor receptor (FGFR) inhibitor presented with spontaneous dysphonia without other etiologic factors.</p> </sec> <sec id="hed23550-sec-0003" sec-type="section"> <title>Results</title> <p>In all cases, we observed a well‐limited mucosal lesion on the superior surface of the anterior portion both vocal folds, symmetrical, sparing the anterior commissure and the vocal process. Histopathology showed necrosis and inflammation. After discontinuation of treatment in 3 patients, their voices improved, but with persistent inflammation in 2 patients and vocal fold scarring in 1 patient.</p> </sec> <sec id="hed23550-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Clinicians should systematically perform laryngoscopy in case of dysphonia in patients treated with angiogenesis inhibitors in order to diagnose laryngeal lesions and rule out differential diagnoses. © 2014 Wiley Periodicals, Inc. <italic>Head Neck</italic> 36: E81–E85, 2014</p> </sec> </abstract>