An overall characterization of pediatric acute lymphoblastic leukemia with 2 overexpression. Issue 10 (17th June 2014)

• Record Type: Journal Article
• Authors: Yano, Mio; Imamura, Toshihiko; Asai, Daisuke; Moriya‐Saito, Akiko; Suenobu, So‐ichi; Hasegawa, Daiichiro; Deguchi, Takao; Hashii, Yoshiko; Kawasaki, Hirohide; Hori, Hiroki; Kosaka, Yoshiyuki; Kato, Koji; Horibe, Keizo; Yumura‐Yagi, Keiko; Hara, Junichi; Matsumoto, Kenji; Kiyokawa, Nobutaka; Oda, Megumi; Sato, Atsushi; for the Japan Association of Childhood Leukemia Study (JACLS)
• Is Part Of: Genes, chromosomes & cancer. Volume 53:Issue 10(2014:Oct.)
• Page Start: 815
• Page End: 823
• Publication Date: 2014-06-17
• Subjects: Cancer -- Genetic aspects -- Periodicals; 616.994042
• DOI: 10.1002/gcc.22190
• Languages: English
• ISSNs: 1045-2257

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>For an overall characterization of pediatric B‐cell precursor acute lymphoblastic leukemia (BCPALL) with <italic>CRLF2</italic> overexpression (OE), we conducted genetic analysis of <italic>CRLF2</italic> in 167 pediatric BCPALL patients. <italic>CRLF2</italic> OE was detected in 30 (18%) of 167 patients, the <italic>P2RY8‐CRLF2</italic> fusion was identified in only 3 (1.8%) of 167 patients, all of which demonstrated <italic>CRLF2</italic> OE. Moreover, <italic>CRLF2</italic> gain was identified in 18 (11%) of 167 patients. Messenger RNA sequencing revealed a novel fusion transcript, <italic>CSF2RA‐CRLF2</italic>, in a case with <italic>CRLF2</italic> OE, suggesting that this fusion is associated with <italic>CRLF2</italic> OE. In survival analysis, no significant differences in 5‐year event‐free survival (EFS) and overall survival were observed between patients with and without <italic>CRLF2</italic> OE (70.7 vs. 75.4%, log rank <italic>P</italic> = 0.68 and 96.4 vs. 82.1%, log rank <italic>P</italic> = 0.11, respectively). However, a significant difference in 5‐year EFS between <italic>CRLF2</italic> OE patients with and without <italic>IKZF1</italic> deletion was observed (44.4 vs. 83.1%, log rank <italic>P</italic> = 0.02). In multivariate analysis, only <italic>IKZF1</italic> deletion was a significant predictor of inferior OS (hazard ratio: 2.427, <italic>P</italic> = 0.04).These findings suggest that <italic>CRLF2</italic> OE is not an independent prognostic factor in pediatric BCPALL. © 2014 Wiley Periodicals, Inc.</p> </abstract>