<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A number of acetophenones is regioselectively bis‐arylated at the Me‐group with 1, 3‐di‐, 1, 2, 4‐tri‐ and 1, 3, 5‐trimethoxybenzenes via I<sub>2</sub>/DMSO‐mediated Friedel‐Crafts reaction.</p> </abstract>