Polymorphisms of COMT Val158Met and DAT1 3′-UTR VNTR in Illicit Drug Use and Drug-Related Psychiatric Disorders. (19th September 2014)

• Record Type: Journal Article
• Authors: Chen, Chih-Ken; Lin, Shih-Ku; Chiang, Shu-Chuan; Su, Lien-Wen; Wang, Liang-Jen
• Is Part Of: Substance use & misuse. Volume 49:Number 11(2014)
• Page Start: 1385
• Page End: 1391
• Publication Date: 2014-09-19
• Subjects: Narcotic habit -- Periodicals; Alcoholism -- Periodicals; Substance abuse -- Periodicals; Behavior, Addictive -- Periodicals; Sustance-Related Disorders -- Periodicals; 362.2905
• DOI: 10.3109/10826084.2014.901391
• Languages: English
• ISSNs: 1082-6084

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>To investigate the involvement of COMT <italic>Val158Met</italic> and DAT1 <italic>3′-UTR VNTR</italic> genotypes in the pathogenesis of illicit drug use and drug-induced psychotic disorders (DIP), 187 substance users and 386 normal controls were recruited from Northern Taiwan. Substance users and normal controls significantly differed in allele frequencies of COMT <italic>Val158Met</italic> (<italic>p</italic> = 0.039) but not in allele frequencies of DAT1 <italic>3′-UTR VNTR</italic> (<italic>p</italic> = 0.879). However, neither allele frequencies of COMT Val158Met nor allele frequencies of DAT1 <italic>3′-UTR VNTR</italic> were associated with DIP. The findings should be confirmed in further studies of a larger sample size and a more homogenous patient group.</p> </abstract>