Non‐steroidal anti‐inflammatory drugs for pain after oral surgery. (16th December 2013)

• Record Type: Journal Article
• Authors: Bailey, E.; Patel, N.; Coulthard, P.
• Is Part Of: Oral surgery. Volume 7:Number 3(2014:Aug.)
• Page Start: 152
• Page End: 161
• Publication Date: 2013-12-16
• Subjects: Mouth -- Surgery -- Periodicals; 617.522059
• DOI: 10.1111/ors.12073
• Languages: English
• ISSNs: 1752-2471

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="ors12073-sec-0001" sec-type="section"> <title>Aim</title> <p>To describe the role of non‐steroidal anti‐inflammatory drugs (NSAIDs) in the management of pain after oral surgery.</p> </sec> <sec id="ors12073-sec-0002" sec-type="section"> <title>Materials and methods</title> <p>A review of the literature describing the pharmacokinetics, benefits and harms of NSAIDs in terms of systematic review evidence, interactions, use in children, pregnancy and breastfeeding.</p> </sec> <sec id="ors12073-sec-0003" sec-type="section"> <title>Results</title> <p>Twelve Cochrane reviews were identified describing the efficacy of NSAIDs for pain after oral surgery. Ibuprofen 400 mg is an effective analgesic [number needed to treat (NNT) = 2.3 in tablet form and 1.8 in soluble form]. Cyclooxygenase‐2 (COX‐2)‐selective NSAIDs also demonstrate low NNTs, based on smaller studies of post‐operative pain. There is association with gastrointestinal, cardiovascular and renal adverse effects.</p> </sec> <sec id="ors12073-sec-0004" sec-type="section"> <title>Conclusions</title> <p>NSAIDs are effective analgesics for moderate pain after oral surgery. The routine use of COX‐2‐selective NSAIDs is not recommended. Careful patient selection is important.</p> </sec> </abstract>