Crystallization of Piroxicam Solid Forms and the Effects of Additives. Issue 8 (9th July 2014)

• Record Type: Journal Article
• Authors: Liu, Guangpu; Hansen, Thomas B.; Qu, Haiyan; Yang, Mingshi; Pajander, Jari P.; Rantanen, Jukka; Christensen, Lars P.; Qu, Haiyan; Rantanen, Jukka; Ulrich, Joachim
• Is Part Of: Chemical engineering & technology. Volume 37:Issue 8(2014:Aug.)
• Page Start: 1297
• Page End: 1304
• Publication Date: 2014-07-09
• Subjects: Chemical engineering -- Periodicals; Chemical processes -- Periodicals; 660.05
• DOI: 10.1002/ceat.201400206
• Languages: English
• ISSNs: 0930-7516

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The relative stabilities of the two anhydrous polymorphs and the monohydrate of piroxicam in ethanol/water mixtures and the crystallization behavior of the solid forms in the presence of 11 additives were studied. At 37 °C, form II is thermodynamically more stable than form I, while the relative stability of form II and the monohydrate depends on the water concentration in the solution. The total Hansen solubility parameter <italic>δ</italic>_T and the hydrogen bonding solubility parameter <italic>δ</italic>_H of the substances can partly explain the effects of the additives on the crystallization of the solid forms. The additives that selectively promoted the crystallization of form I are the ones with <italic>δ</italic>_T and <italic>δ</italic>_H parameters similar to those of piroxicam.</p> </abstract>