Target site pharmacokinetics of linezolid after single and multiple doses in diabetic patients with soft tissue infection. (20th May 2014)

• Record Type: Journal Article
• Authors: Eslam, Roza Badr; Burian, Angela; Vila, Greisa; Sauermann, Robert; Hammer, Alexandra; Frenzel, Dorothea; Minichmayr, Iris K.; Kloft, Charlotte; Matzneller, Peter; Oesterreicher, Zoe; Zeitlinger, Markus
• Is Part Of: Journal of clinical pharmacology. Volume 54:Number 9(2014:Sep.)
• Page Start: 1058
• Page End: 1062
• Publication Date: 2014-05-20
• Subjects: Pharmacology -- Periodicals; Pharmacology -- Periodicals; Pharmacology, Clinical -- Periodicals; 615.1
• DOI: 10.1002/jcph.296
• Languages: English
• ISSNs: 0091-2700

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="jcph296-sec-0001" sec-type="section"> <p>The underlying pathology of diabetic wounds, i.e. impairment of macro‐ and microcirculation, might also impact target site penetration of antibacterial drugs. To compare tissue concentrations of linezolid in infected and not infected tissue 10 patients suffering from type 2 diabetes with foot infection were included in the study. Tissue penetration of linezolid was assessed using in vivo microdialysis at the site of infection as well as in non‐inflamed subcutaneous adipose tissue. All patients were investigated after receiving a single dose of linezolid and five patients in addition at steady state. After a single dose of linezolid significantly higher area under the concentration vs. time curve over 8 hours (AUC<sub>0–8</sub>) and maximum concentrations (C<sub>max</sub>)‐values were observed in plasma (65.5 ± 21.2 mg*h/L and 16.4 ± 4.6 mg/L) as compared to inflamed (36.3 ± 22.9 mg*h/L and 6.6 ± 3.6 mg/L) and non‐inflamed tissue (33.0 ± 17.7 mg*h/L and 6.7 ± 3.6 mg/L). Multiple administrations of linezolid led to disappearance of significant differences in C<sub>max</sub> and AUC<sub>0–8</sub> between plasma, inflamed, and non‐inflamed tissue. Approximately 2‐fold increase of C<sub>max</sub> and AUC<sub>0–8</sub>‐values in tissue was observed at steady state as compared to the first administration. Penetration of linezolid is not impaired in diabetic foot infection but equilibrium between plasma and tissue might be delayed.</p> </sec> </abstract>