A Simple Assay for Quality Binders to Cucurbiturils. Issue 32 (7th July 2014)

• Record Type: Journal Article
• Authors: Vázquez , Julián; Remón , Patricia; Dsouza, Roy N.; Lazar, Alexandra I.; Arteaga, Jesús F.; Nau, Werner M.; Pischel, Uwe
• Is Part Of: Chemistry. Volume 20:Issue 32(2014)
• Page Start: 9897
• Page End: 9901
• Publication Date: 2014-07-07
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201403405
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A new approach towards the rapid identification of quality binders to cucurbiturils—those that combine high affinity with high selectivity for a particular homologue—was developed. The assay exploits macrocycle‐specific optical fingerprints (colorimetric or fluorimetric) of carefully selected indicators dyes. The screening of a guest library revealed known (e.g., adamantane derivatives) and new (e.g., terpenes) quality binders. The predictive power of the assay was underpinned by the modeling of the involved thermodynamic equilibria.</p> </abstract>