Induced Chirality in a Metal–Organic Framework by Postsynthetic Modification for Highly Selective Asymmetric Aldol Reactions. Issue 8 (14th July 2014)

• Record Type: Journal Article
• Authors: Demuynck, Anneleen L. W.; Goesten, Maarten G.; Ramos‐Fernandez, Enrique V.; Dusselier, Michiel; Vanderleyden, Jozef; Kapteijn, Freek; Gascon, Jorge; Sels, Bert F.
• Is Part Of: ChemCatChem. Volume 6:Issue 8(2014:Aug.)
• Page Start: 2211
• Page End: 2214
• Publication Date: 2014-07-14
• Subjects: Catalysis -- Periodicals; 541.39505
• DOI: 10.1002/cctc.201402082
• Languages: English
• ISSNs: 1867-3880

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A straightforward synthetic route to chiral metal–organic frameworks is proposed that relies on an acid–base interaction between an acid linker and a chiral primary amino acid derived diamine organocatalyst. High <italic>ee</italic> values for the aldol condensation of linear ketones and aromatic aldehydes are reported with this heterogeneous catalyst. Three consecutive catalyst reuse experiments demonstrated that the majority of the activity was preserved, as was the enantioselectivity.</p> </abstract>